By Benny K. C. Lo
This ebook provides state of the art options in antibody engineering. partly 1, well known assets for antibody series research are defined, including in-depth discussions on antibody structural modeling.
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Additional info for Antibody Engineering, Methods and Protocols
Wu, T. , Perry, H. , Gottesman, K. , and Foeller, C. (1991) Sequences of proteins of immunological interest. , pp. 91–3242. 35. , Cohen, G. , Padlan, E. , and Davies, D. R. (1986) Phosphocholine binding immunoglobulin Fab McPC603. J. Mol. Biol. 190: 593–604. 36. Chothia, C. and Lesk, A. M. (1987) Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol. 196, 901–917. 37. -P. (2000) Web sites of interest to immunologists, in Current Protocols in Immunology, J. Wiley and Sons, New York, NY, pp.
This exception, 43c9, results from a substitution of Ile by Val at residue L:N + 1. It was decided to add this conservative substitution to the range of allowed residues for this class. 4. Class 4 (16 Residues) Of the 32 instances of 16-residue L1s, all but four are conformational members of this class, but only 16 fit the canonical rules. As with class 2, all but one L1 could be returned to this class by expanding the definitions to include conserved substitutions, with one exception. 1kem has Phe rather than Ser at L1:N + 1, a substitution that slightly perturbs the structure.
32 Lefranc Fig. 3. Example of IMGT/LIGM-DB resulting screen for the “View” choice. 2. Concept of Description: Standardized Sequence Annotation One hundred and seventy-seven feature labels are needed to describe all structural and functional subregions that compose IG and TR sequences (7), whereas only seven of them are available in EMBL, GenBank, or DDBJ. Annotation of sequences with these labels constitutes the main part of the expertise. Levels of annotation have been defined that allow the users to query sequences in IMGT/LIGM-DB, although they are not fully annotated (7).
Antibody Engineering, Methods and Protocols by Benny K. C. Lo