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Additional resources for Annual Review of Immunology Volume 12 1994

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Immunol. 12:1-62. org by HINARI on 08/30/07. For personal use only. ON THINKING AND WISDOM 39 once again we learned nothing from it. It was well-established that peptide derived from protein could be complexed to RNAand that the complex was immunogenic but the ’"so what" was missing. This remains another example of a popular idea with experimental support that disappeared without as much as a whimper because it had no conceptual foundation and its disappearance was irrelevant, independent of whether the idea was actually right or wrong.

In essence, there is at present no validly competingmodel. In order to develop its pathway, I state its elements as we understand them today and then show how manywrong steps and filling in of incompletenesses were necessary to arrive at the present model. This is howwe learn; peer criticism wouldhave hastened the process, but the concept was essentially ignored until recently whenit gained a dubious notoriety. There are several essential elements: I. The S/NS discrimination is a learned process; it cannot be germline encoded for immunesystems as it is for the defense mechanisms of invertebrates and plants.

Wehad to abandon the terms "germline" and "somatically derived" dueto their confuseduse after the discoveryof recombination andsplicing of gene segments. There Were Many GODs To Choose From In 1968,Lennoxand I (83) had categorizedthe viewsof howthe repertoire is generatedby the table shownbelow: Annual Reviews ON THINKING AND WISDOM 43 Table 1 Modelsof origin of varieties in antibodies" Variety originates in v during Association of genes v and c in germ line Evolution germ-line models Differentiation somatic models v and c form one cistron, vc v and c are separate cistrons Szilard Dreyer & Bennett Brenner & Milstein Lennox & Cohn Annu.

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