Amphioxus immunity : tracing the origins of human immunity by An-Long Xu PDF

By An-Long Xu

ISBN-10: 0128096470

ISBN-13: 9780128096475

ISBN-10: 0128499036

ISBN-13: 9780128499030

Amphioxus Immunity: Tracing the foundation of Human Immunity covers a extraordinary variety of data approximately Amphioxus and its evolutionary context. This compilation of what's presently recognized approximately Amphioxus, with a pointy specialize in its immune method, contains thirteen themes, such as:

  • Amphioxus as a version for figuring out the evolution of vertebrates
  • basic wisdom of immunology
  • immune organs and cells of amphioxus
  • a genomic and transcriptomic view of the Amphioxus immunity
  • pattern reputation procedure in Amphioxus
  • transcription components in Amphioxus
  • the supplement process of Amphioxus
  • the oxidative burst procedure in Amphioxus
  • immune effectors in Amphioxus
  • lipid signaling of immune reaction in Amphioxus
  • apoptosis in amphioxus; primitive adaptive immune process of Amphioxus
  • and destiny study directions

This helpful reference ebook is loaded with details that may be helpful for an individual who needs to profit extra concerning the foundation of vertebrates and adaptive immunity.

  • Provides new proof at the foundation of the adaptive immune process, the evolution of innate immunity, and evolution-stage particular immune protection mechanisms
  • Not in simple terms provides the cells and molecules concerned with the adaptive immune reaction in Amphioxus, but additionally characterizes the origination and evolution of the gene households and pathways desirous about innate immunity
  • Includes a lot pioneering paintings, from the molecular, genomic, and mobile to the person level

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Additional info for Amphioxus immunity : tracing the origins of human immunity

Example text

However, if other agonists such as silica and asbestos are encountered, which are hard to clear, the inflammation will persist and cause serious injury. Usually, the inflammatory response is an effective protective strategy that can use the innate and adaptive immunity components to protect hosts. In the inflammatory response, different cytokines are critical and bridge the responses of different immune cells. Cytokines from different source once had different names, such as lymphokines secreted by lymphocytes, monokines secreted by monocytes and macrophages; some cytokines were referred as interleukins and some as chemokines.

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437, 1167–1172. , 2008. TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 28, 651–661. , 2004. The role of scavenger receptors in pathogen recognition and innate immunity. Immunobiology 209, 39–49. , 2007. Notch signalling during peripheral T-cell activation and differentiation. Nat. Rev. Immunol. 7, 64–75. , 2002. Role of thymic organ structure and stromal composition in steady-state postnatal T-cell production.

Science 314, 997–1001. , 2008. Innate immune response triggered by influenza a virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNARI-dependent pathway. J. Immunol. 180, 2034–2038. , 2011. RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. Immunity 34, 340–351. , 2014. Pattern recognition and signaling mechanisms of RIG-I and MDA5. Front. Immunol. 5, 342. The sterile inflammatory response. Annu.

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Amphioxus immunity : tracing the origins of human immunity by An-Long Xu

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