AIDS-Associated Viral Oncogenesis (Cancer Treatment and - download pdf or read online

By Craig Meyers

ISBN-10: 0387468048

ISBN-13: 9780387468044

ISBN-10: 0387468161

ISBN-13: 9780387468167

One of crucial facets of AIDS is the lack of protecting immune functionality within the contaminated host which ends up in elevated incidence of opportunistic infections and cancers. This e-book particularly addresses viral-induced human cancers linked to AIDS and saw within the AIDS inhabitants. It addresses the explicit remedy required during this precise inhabitants and the molecular biology of the causative viral agents.

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Extra resources for AIDS-Associated Viral Oncogenesis (Cancer Treatment and Research)

Sample text

205 A pilot study using cidofovir for the treatment of AIDS-associated and classic KS showed no effect on disease progression, no decrease in viral load of HHV-8 among seven patients, and no change in expression of early lytic and latent gene expressions from cutaneous KS lesions. This resistance can be overcome by inducing HHV-8 to reenter the lytic cycle during antiviral therapy, leading to destruction of virally infected cells. 207 Other Potential Targets Potential targets based on KS pathogenesis are the focus of many current trials.

28 CLINICAL PRESENTATION OF PCNSL Clinical presentation of CNS lymphoma may be characterized by headaches, confusion, lethargy, memory loss, hemiparesis, aphasia, and seizures. 14,29 The lesions are usually large, few in number, and contrast enhanced on neuroimaging. Without treatment most patients with PCNSL are likely to die within three months, even in the absence of AIDS. 31 Methotrexate administered intravenously is able to penetrate the blood–brain barrier and achieve levels high enough to be cytotoxic.

Mortality from MCD and its resulting complications was 45% in this series. Steroids are generally used along with chemotherapy, thus results are limited in treatment for MCD. 226 42 AIDS-Associated Viral Oncogenesis Antiviral Therapy Inconsistent results have been reported in various studies from the use of antiviral therapy targeting HHV-8. For instance, remission of HIV-associated MCD, along with a decline in plasma HHV-8 DNA levels, was attained in three patients treated with intravenous ganciclovir therapy.

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AIDS-Associated Viral Oncogenesis (Cancer Treatment and Research) by Craig Meyers

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