Get Advances in Immunology, Vol. 97 PDF

By Frederick W. Alt

ISBN-10: 0123743249

ISBN-13: 9780123743244

Advances in Immunology, a usual and hugely revered ebook, offers present advancements in addition to accomplished reports in immunology. Articles tackle the wide variety of issues that include immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and scientific modalities. Edited and authored by way of the major scientists within the box, each one quantity offers up to date info and instructions for destiny study.

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Extra info for Advances in Immunology, Vol. 97

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This suggests that while ROCK is likely required for uropod maintenance through effects on myosin, it is not responsible for ERM-mediated cytoskeletal anchoring of cellular receptors. , 2003). , 2002). , 2007). , 2002). In addition, other emerging cytoskeletal regulatory effectors are likely to regulate chemotaxis. , 2006), have not yet focused on T cell 48 Timothy S. Gomez and Daniel D. Billadeau chemotaxis. However, recent studies of other leukocyte subsets indicate a role for this complex in migration.

As a result, ERM-mediated plasma membrane and cortical F-actin linkage is severed, leading to reduced cellular rigidity, increased cell-surface protein mobility, and 28 Timothy S. Gomez and Daniel D. , 2004). , 2001). Following antigenic stimulation, ERM proteins are rapidly reactivated, localizing to and regulating the formation of the actin-rich distal pole complex (DPC), a posterior cap-like structure forming opposite the IS (Fig. 2). , 2004). , 2004). , 2007). 4. , 1982; Kuhn and Poenie, 2002).

While other CRK family adaptors might compensate in this model, it is also possible that other RAP1 GEFS activate RAP1 in the absence of C3G. , 2004b), a potent PKC activator that is capable of promoting integrin clustering and affinity maturation independent of the TCR. , 2004b). Thus it remains possible that the combination of both C3G and CALDAG-GEF regulates TCR-stimulated activation of RAP1. 34 Timothy S. Gomez and Daniel D. Billadeau The exact mechanism by which active RAP1 promotes integrin clustering is unclear.

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Advances in Immunology, Vol. 97 by Frederick W. Alt

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