By Frank J. Dixon
From the experiences of past Volumes "Provides unrivalled price in either educational and financial phrases and may be bought by means of demanding pressed librarians as a tremendous precedence to be jealously defended." -JOURNAL OF clinical MICROBIOLOGY "Advances in Immunology needs to locate itself one of the such a lot energetic volumes within the libraries of our universities and institutions." -SCIENCE "A provocative and scholarly assessment of research." -JOURNAL OF the yankee clinical organization "Deserves an everlasting position in biomedical libraries as an relief in study and in teaching." -JOURNAL OF IMMUNOLOGIC equipment
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Extra resources for Advances in Immunology, Vol. 55
1990b). Hence, SCF is not an obligate growth factor for the proliferation of mouse pro-B cells. Taken together, these data indicate that SCF is a potent comitogen for normal B220+ pre-B cells and certain pre-B cell lines, but cannot replace the stromal signal necessary for the proliferation of normal pro-B cells. s2 STEPHEN J. GALL1 ET A L X. Mast Cell Biology A. MASTCELLDEVELOPMENT Mast cells are distributed throughout essentially all vascularized mammalian tissues, where they occur in close proximity to blood vessels, nerves, epithelia, and smooth muscle.
1993) indicate that one may mot be able to establish a direct correlation between patterns of transcription of early response genes per se and subsequent cell proliferation. For example, Tsai et al. (1993) found that both SCF (50 nglml) and IL-3 (100 pg/ml) exerted strong mitogenic effects on quiescent mouse BMCMCs and, in parallel, induced increased accumulation of early response gene mRNA levels. However, IL-3 at 50 pg/ml also induced significant proliferation of quiescent cells, but produced little or no change in the cells’ levels of early response gene mRNAs.
1992). Similarly, SCF by itself has only modest effects on the development of colonies of hematopoietic cells in uitro, but acts in synergy with many other growth factors to promote the production in vitro of early and intermediate precursors of erythroid, myeloid, and lymphoid lineages. 40 STEPHEN J. , 1991). However, SCF also can act synergistically with other growth factors to promote mast cell proliferation. For example, SCF can act synergistically with IL-3 to promote the in uitro proliferation of immature mouse mast cells (S.
Advances in Immunology, Vol. 55 by Frank J. Dixon