Download e-book for iPad: Advanced Drug Formulation Design to Optimize Therapeutic by Robert O. Williams, David R. Taft, Jason T. McConville

By Robert O. Williams, David R. Taft, Jason T. McConville

ISBN-10: 1420043870

ISBN-13: 9781420043877

Textual content discusses nanoparticle platforms for melanoma remedies, and in addition provides innovative immono-regulation brokers for transplantation and the neighborhood concentrating on of substances, in particular poorly water soluble medicinal drugs to supply better healing results. additionally, this identify highlights components of treatment exhibiting the main promise for development in medical results through complex formula layout.

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However, Nebulizer systems have many draw backs. For example, historically, nebulizers have been cumbersome, often being used at home or in a clinical setting. Furthermore, they deliver medication over a long timescale and have a complexity of device assembly with low efficiency and high variability in drug delivery (136–138). The most common type of nebulizer is the air-jet nebulizer (139). Jet nebulizer devices utilize a pressurized gas to create the aerosol particles (140). The gas stream is passed over the solution, creating a liquid film.

Apart from direct morphological and surface roughness parameters, one of the key factors that have been suggested to influence aerosolization performance of adhered drug particulates is the presence of similar sized excipient fines, for example, particles with a volume median diameter <5 mm. Figure 7 AFM topographical images of (A) a commercial grade lactose carrier surface and (B) surface-etched carrier. Source: From Ref. 26. Advances in Pulmonary Therapy 13 The “positive” effect of excipient fines for drug aerosolization would also be expected since the surface of a commercial grade lactose carrier, as represented in Figure 8, will contain a distribution of “energy” sites that will promote particle adhesion to different degrees (16), and thus affect drug particle liberation in DPI carrier based systems (30).

The mechanism for improved performance in these systems is dependent on both the previously described formulation factors, and the relative cohesive/adhesive balance between the components involved. Recently, direct measurement of inter-particulate forces in conventional DPI systems has shown that a clear balance may be observed between the adhesion and cohesion profiles of each component in the formulation (33,34), and these factors may be used to predict the performance of the formulation. Such observations are also in good correlation with previous studies that predict ordered mixing in tableting ingredients (35).

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Advanced Drug Formulation Design to Optimize Therapeutic Outcomes by Robert O. Williams, David R. Taft, Jason T. McConville


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