25 Years of P53 Research - download pdf or read online

By Pierre Hainaut, Klas G. Wiman

ISBN-10: 1402029209

ISBN-13: 9781402029202

ISBN-10: 1402029225

ISBN-13: 9781402029226

The invention of p53 in 1979 marks the start of a such a lot attention-grabbing period of recent melanoma examine and molecular biology, an period that continues to be in complete swing and doesn't convey any indicators of finishing within the foreseeable destiny. p53 has emerged as a key tumor suppressor and critical objective for novel melanoma treatment. For round 10 years, p53 was once thought of an oncogene with a little bit strange good points. even if, an important paradigm shift happened round 1988-89 whilst interesting new findings tested that ordinary (wild kind) p53 might inhibit transformation of cells in tradition and that the p53 gene used to be mutated in a wide fraction of human tumors. in truth, p53 looked to be the main often mutated gene in melanoma cells. next paintings in the course of the 1990’s confirmed that p53 was once a transcription issue that regulates many different genes, and that p53 can set off apoptosis, the suicide software of the phone. This e-book, written through world-leading p53 researchers together with a lot of those that have formed the sector over the last 25 years, presents special insights into the development of the p53 box and the clients for higher melanoma prognosis and remedy sooner or later. it's going to be of curiosity to every body operating in melanoma learn, medical oncology, and molecular biology, and certainly to anyone drawn to technological know-how, drugs, in addition to in contemporary advancements of the guidelines and ideas of the molecular biology of melanoma.

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Additional resources for 25 Years of P53 Research

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Although they show that the peptide does not alter p53 levels upon internalization, it is not clear that there is similar internalization of the peptide in different cell lines. A key experiment would be to use the chromatin immunoprecipitation assay to test directly whether it is the DNA binding activity per se that is being affected by these treatments. SUMMARY Recent studies regarding the regulation of p53-mediated transcriptional activation suggest that a critical question is what and when other coactivators are recruited to the promoters of p53 target genes.

25 Years of p53 Research, 27-51. © 2005 Springer. Printed in the Netherlands. 28 Chapter 2 R248 R273 R175 G245 R249 AD1 1 20 AD2 40 R282 PXXP 60 TETRA 90 97 100 300 320 360 363 393 Figure 1. fr/p53). Indicated are the N-terminal activation domains (AD1, AD2), the proline rich region (PXXP), the central core sequence specific DNA binding domain (DNA BINDING CORE), the tetramerization domain (TETRA) and the C-terminal sequence non-specific nucleic acid binding region (BASIC). TRANSACTIVATION DOMAIN The first 100 amino acids of p53 contain two transactivation domains, a proline-rich domain and a nuclear export signal.

2004). , 2001). While they do not observe a difference in p21 promoter occupancy of the p53 mutant, they do observe a defect in the recruitment of the CBP histone acetyltransferase (as well as other coactivators such as TRAAP) to the promoter. , 2004). Therefore it appears that the reported differences in the precise role of p53 acetylation in the recruitment of coactivators could be the result of surprisingly different regulation of two closely related proteins. Since the C-terminal lysines could be sites of posttranslational modifications other than acetylation and could therefore have multiple effects when mutated in vivo, further experiments would be useful in resolving this question.

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25 Years of P53 Research by Pierre Hainaut, Klas G. Wiman

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